T-cell exhaustion and stemness in antitumor immunity: Characteristics, mechanisms, and implications

T-cell exhaustion and stemness in antitumor immunity: Characteristics, mechanisms, and implications

Blog Article

T cells play a crucial role in the regulation of immune response and are integral to the efficacy of cancer immunotherapy.Because immunotherapy has emerged as a promising treatment for cancer, increasing attention has been focused on the differentiation and function of T cells in immune response.In this review, we describe the Exhaust Systems research progress on T-cell exhaustion and stemness in the field of cancer immunotherapy and summarize advances in potential strategies to intervene and treat chronic infection and cancer by reversing T-cell exhaustion and maintaining and increasing T-cell stemness.Moreover, we discuss therapeutic strategies to overcome T-cell immunodeficiency in the tumor microenvironment and promote continuous breakthroughs in the Electric Massagers anticancer activity of T cells.